Lineage-based identification of cellular states and expression programs
نویسندگان
چکیده
منابع مشابه
Lineage-based identification of cellular states and expression programs
We present a method, LineageProgram, that uses the developmental lineage relationship of observed gene expression measurements to improve the learning of developmentally relevant cellular states and expression programs. We find that incorporating lineage information allows us to significantly improve both the predictive power and interpretability of expression programs that are derived from exp...
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In multicellular organisms, cells usually respond to signals that they encounter in a manner that depends on their particular lineage 'identity'. In other words, cells that have identical genomes can respond in markedly different ways to the same stimulus, with the outcome being determined largely by the previous developmental history of the cell. This general observation implies that individua...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2012
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/bts204